Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study

Zamora-Ros, Raul; Fedirko, Veronika; Trichopoulou, Antonia; González, Carlos A.; Bamia, Christina; Trepo, Elisabeth; Nöthlings, Ute; Duarte-Salles, Talita; Serafini, Mauro; Bredsdorff, Lea; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte; Fagherazzi, Guy; Perquier, Florence; Boutron-Ruault, Marie-Christine; Katzke, Verena; Lukanova, Annekatrin; Floegel, Anna; Boeing, Heiner; Lagiou, Pagona; Trichopoulos, Dimitrios; Calogero, Saieva; Agnoli, Claudia; Mattiello, Amalia; Tumino, Rosario; Sacerdote, Carlotta; Bueno-de-Mesquita, H. Bas; Peeters, Petra H. M.; Weiderpass, Elisabete; Engeset, Dagrun; Skeie, Guri; Argüelles, Marcial Vicente; Molina-Montes, Esther; Dorronsora, Miren; Tormo, María José; Ardanaz, Eva; Ericson, Ulrika; Sonestedt, Emily; Sund, Malin; Landberg, Rikard; Khaw, Kay-Thee; Wareham, Nicholas J.; Crowe, Francesca L.; Riboli, Elio; Jenab, Mazda

doi:10.1002/ijc.28257

Research article2013Peer reviewedOpen access

Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study

Zamora-Ros, Raul; Fedirko, Veronika; Trichopoulou, Antonia; González, Carlos A.; Bamia, Christina; Trepo, Elisabeth; Nöthlings, Ute; Duarte-Salles, Talita; Serafini, Mauro; Bredsdorff, Lea; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte; Fagherazzi, Guy; Perquier, Florence; Boutron-Ruault, Marie-Christine; Katzke, Verena; Lukanova, Annekatrin; Floegel, Anna; Boeing, Heiner;
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Abstract

What's new? Coffee, tea, fruits and vegetables, and certain other foods may protect against hepatocellular carcinoma (HCC), thanks to their antioxidant ingredients. This study lends fresh support to that idea, revealing specifically that dietary flavanols, which possess antioxidant activity, could play a favourable role in HCC prevention. Dietary antioxidant capacity from coffee intake in particular was found to be inversely associated with HCC risk, though statistical significance was lost after exclusion of the first two years of follow-up. Assessment of the bioavailability of flavonoids and other antioxidants is needed to confirm links between antioxidant intake and HCC risk.

Keywords

flavonoids; lignans; dietary intake; antioxidant capacity; hepatocellular carcinoma; EPIC

Published in

International Journal of Cancer
2013, Volume: 133, number: 10, pages: 2429-2443
Publisher: WILEY-BLACKWELL

SLU Authors

Landberg, Rikard
- Department of Molecular Sciences, Swedish University of Agricultural Sciences

Sustainable Development Goals

SDG3 Ensure healthy lives and promote well-being for all at all ages

UKÄ Subject classification

Nutrition and Dietetics
Cancer and Oncology

Publication identifier

DOI: https://doi.org/10.1002/ijc.28257

Permanent link to this page (URI)

https://res.slu.se/id/publ/55555